Indication intelligence, analysis and sector perception

RegMed Investors (RMi) Research Note: Harvard Apparatus GT (OTCQB):Navigating the next re-calibration, yet another "Exempt Offering of Securities"

August 10, 2025

On October 31, 2013, Harvard Bioscience (HBIO), spun-off contributing its regenerative medicine business assets, plus $15 M of cash, into Harvard Apparatus Regenerative Technology, then it became Biostage (OTCQB: BSTG) and now back to its present, Harvard Apparatus Regenerative Technology (OTCQB: HRGN).  Twelve (12) years, Nine (9) private placements (PPM), 3 corporate re-names, 4 CEOs, 2 presidents, 5 CFOs with still NO clinical response <patient recruitment issues> since the November 1, 2013 spin-off completed. Now, they’re all but BROKE filing for yet another PPM to come! What valuation model would even/ever justify this PPM pricing? WHO is their major shareholder – DST Capital, OTCQB: HRGN’s in-house fund run by its president Hong Yu, funded by Mrs. bin (Zhao) of Weston, Mass. Will an “Exempt Offering of Securities” emanate from its board management and “quiet” < Lui Dong Hai, chairman of Dixintong Technology Group (D. Phone, the largest smartphone retailer in China) the husband of Mrs. bin (Zhao)> majority members are from or reside in Beijing, PRC. Are they up to their old tricks, they just don’t stop? Challenging facts state the obvious – a Ponzi Scheme, a Madoff look-a-like or just a PRC, Communist China “listening/monitoring post” in Holliston, Mass? U.S. investors BEWARE, forewarned is forearmed?            

RegMedInvestors (RMi) Finance note: Prime Medicine (PRME) closes 43.7 M share offering at $3.30

August 1, 2025

PRME closed Friday at $4.04 ... And the full exercise of the 5.7 K underwriters’ option at $3.30 per share. The gross proceeds before deducting underwriting discounts and commissions and offering expenses, were approximately $144.2 M. TD Cowen and BMO Capital Markets are acting as joint book-running managers for the proposed offering.

News: RegMedInvestors (RMi) Research Note: Verve Therapeutics (VERV) to be acquired by Eli Lilly (LLY)

June 17, 2025

Gene therapy companies are riding a new waave ... Verve Therapeutics (VERV +$4.79 or +76.31 to $11.06) rallied after the gene editing company agreed to be acquired by Eli Lilly (LLY -$9.13 or -1.15% to $798.28) or $10.50 per share, a premium of 67.5% on the company’s last close. The deal, which is worth up to $1.3 billion, is expected to close in Q3/25.  The 2 companies were already partnered on a handful of 1-time treatments for cardiovascular diseases. VERV's leading program would use gene editing to permanently turn off the PCSK9 gene. The gene makes a protein that, when elevated, leads to high cholesterol. LLY also agreed to pay an additional $3 per share in a contingent value right. Lilly will pay the CVR when the first patient receives Verve's leading drug in a U.S. P3 study for atherosclerotic cardiovascular disease.